small interfering RNA Archives

Inclisiran for the treatment of hypercholesterolaemia

Joel C Marrs, Sarah L Anderson

Article Type

Review

Published

28 Nov 2024

This narrative review presents and examines current evidence regarding the use of inclisiran for the treatment of hyperlipidaemia and its potential role to reduce cardiovascular events.

RNA interference therapy in cardiology: will new targets improve therapeutic goals?

Renata TJ Fazoli, Luciano F Drager, Roberto Kalil-Filho, Giuliano Generoso

Article Type

Review

Published

20 Aug 2024

This review highlights the historical timeline of the development of siRNA-based drugs, their clinical indications, potential side-effects and future perspectives.

Lipid-lowering interventions targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): an emerging chapter in lipid-lowering therapy

Constantine E Kosmas, Eddy DeJesus, Rosmery Morcelo, Frank Garcia, Peter D Montan, Eliscer Guzman

Article Type

Review

Published

22 Nov 2017

This review aims to present and discuss the current clinical and scientific data pertaining to lipid-lowering interventions targeting PCSK9.