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Three once-weekly intra-articular injections of Hylan G-F 20 significantly improve pain relief compared with placebo in patients with chronic idiopathic knee osteoarthritis: a single-centre, evaluator-blinded and patient-blinded, randomized controlled trial

Michael Langworthy, Peter Lascarides, Wilson Ngai, Kevin Steele, Yili Huang

Article Type

Original Research

Published

05 Apr 2024

This study was conducted to determine the efficacy and safety of three once-weekly injections of intra-articular Hylan G-F 20 in patients with chronic knee osteoarthritis over 26 weeks. It was hypothesized that Hylan G-F 20 would provide significant pain relief with no increased safety risk compared with IA saline (placebo).

Prazosin for the management of behavioural and psychological symptoms of dementia

Rajesh R Tampi, Deena J Tampi, Syeda Arshiya Farheen, Mahwish Adnan, Dhweeja Dasarathy

Article Type

Review

Published

01 Jul 2022

The goal of this report is to identify, from a systematic review of the literature, the evidence for using prazosin in the management of behavioural and psychological symptoms of dementia including agitation and aggression from controlled studies.