Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Katayoun Derakhchan, Zhen Lou, Hong Wang, Robert Baughman

Article Type

Original Research

Published

Prucalopride is a selective serotonin type 4 (5-HT4) receptor agonist indicated for treatment of chronic idiopathic constipation in adults. 5-HT4 receptors are present in the central nervous system; therefore, this article discusses non-clinical and clinical assessments evaluating the tissue distribution and abuse potential of prucalopride.

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Neonatal pharmacology and clinical implications

Antonio Ruggiero MD, Anna Ariano MD, Silvia Triarico MD, Michele Antonio Capozza MD, Pietro Ferrara MD, Giorgio Attinà MD

Article Type

Review

Published

This review article analyses the main pharmacokinetic aspects (ADME) that exist during the neonatal period and offers a description of the physiological background for variability in pharmacological dosing.

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