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Clinical remission and control in severe asthma: agreements and disagreements

Annamaria Bosi, Carlo Lombardi, Cristiano Caruso, Marcello Cottini, Ilaria Baglivo, Stefania Colantuono, Francesco Menzella

Article Type

Review

Published

23 Sep 2024

This narrative review aims to frame the evolution of the debated concept of clinical remission as an ambitious and now concretely achievable outcome in modern asthma management, to highlight correct management of inhaled therapies, oral corticosteroids and biological drugs in this context, and, finally, to provide clinicians with insights that could be useful to achieve remission in the greatest possible number of patients.

Efficacy and steroid-sparing effect of benralizumab: has it an advantage over its competitors?

Francesco Menzella MD, Mirella Biava Msc, Diego Bagnasco MD, PhD, Carla Galeone Msc, Anna Simonazzi MD, Patrizia Ruggiero Msc, Nicola Facciolongo MD

Article Type

Review

Published

15 Apr 2019

This article is an indirect comparison among literature data, especially between OCS reduction studies (ZONDA-SIRIUS) and pivotal studies (SIROCCO-MENSA), evaluating whether the clinical efficacy and the steroid-sparing effect of benralizumab may represent an advantage over other compounds. This data could help the clinician in the decision process of treatment choice, within the different available therapeutic options for eosinophilic refractory severe asthma.