Severe hypereosinophilia in a patient treated with dupilumab and shift to mepolizumab: the importance of multidisciplinary management. A case report and literature review

Sara Munari, Giulia Ciotti, Walter Cestaro, Lorenzo Corsi, Silvia Tonin, Andrea Ballarin, Ariel Floriani, Cristina Dartora, Annamaria Bosi, Matteo Tacconi, Francesco Gialdini, Michele Gottardi, Francesco Menzella

Article Type

Review

Published

This article describes a case of severe hypereosinophilia in a patient with chronic rhinosinusitis with nasal polyps and asthma treated with dupilumab and a subsequent therapeutic shift to mepolizumab that led to maintenance of symptom control and concomitant normalization of blood eosinophil count.

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Targeting eosinophils: severe asthma and beyond

Marco Caminati MD, Francesco Menzella MD, Lucia Guidolin MD, Gianenrico Senna MD

Article Type

Review

Published

This review summarizes the rationale for the use of biologics in eosinophilic diseases and their mechanisms of action.

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