Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Katayoun Derakhchan, Zhen Lou, Hong Wang, Robert Baughman

Article Type

Original Research

Published

Prucalopride is a selective serotonin type 4 (5-HT4) receptor agonist indicated for treatment of chronic idiopathic constipation in adults. 5-HT4 receptors are present in the central nervous system; therefore, this article discusses non-clinical and clinical assessments evaluating the tissue distribution and abuse potential of prucalopride.

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Pharmacotherapy patterns in patients with chronic idiopathic constipation beginning treatment with linaclotide or lubiprostone in the United States

Arpita Nag PhD, Rebecca Bornheimer BA, Gerry Oster PhD

Article Type

Original Research

Published

The objective of this retrospective cohort study was to examine patterns of use of linaclotide and lubiprostone, primarily focusing on duration of treatment and switching between agents, in patients with CIC, with and without IBS, using a large US health insurance claims database.

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