Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Katayoun Derakhchan, Zhen Lou, Hong Wang, Robert Baughman

Article Type

Original Research

Published

Prucalopride is a selective serotonin type 4 (5-HT4) receptor agonist indicated for treatment of chronic idiopathic constipation in adults. 5-HT4 receptors are present in the central nervous system; therefore, this article discusses non-clinical and clinical assessments evaluating the tissue distribution and abuse potential of prucalopride.

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