Review
In the recent era, SGLT-2 inhibitors have shown success in decreasing cardiovascular mortality in the type 2 diabetes mellitus population. This article will help the reviewer to comprehend the pathophysiology of heart failure and the potential role of SGLT-2 inhibitors in the management algorithm of heart failure and its associated risk factors in type 2 diabetes mellitus.
Review
This review discusses the current challenges in the management of cardiovascular disease; the available evidence on the effects of methotrexate on inflammation, blood pressure, and surrogate markers of arterial function; suggestions for future research directions; and practical considerations with the use of methotrexate in this context.
Original Research
This systematic review provides complete and updated information on efficacy and safety of sublingual immunotherapy (SLIT) formulations for the treatment of allergic respiratory diseases (ARDs).
Review
A novel class of targeted therapy has been approved for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. There are currently three approved agents, which are oral cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. In this review, all available data is summarized, unanswered questions are highlighted, and pharmacological differences between each CDK4/6 inhibitor are discussed.
Original Research
Eosinophilic fasciitis is an uncommon connective tissue disorder. Systemic corticosteroids can induce remission of disease; however, there is no universally accepted treatment ladder for eosinophilic fasciitis. This case series evaluates treatment efficacy in patients with eosinophilic fasciitis.
