Articles

Impact of adalimumab on clinical outcomes, healthcare resource utilization, and sick leave in patients with ankylosing spondylitis: an observational study from five Central and Eastern European countries

Daniela Opris-Belinski MD, PhD, Shandor F Erdes MD, PhD, Simeon Grazio MD, PhD, Ladislav Šenolt MD, PhD, Maja Hojnik MD, PhD, Orsolya Nagy MD, PhD, Diana Marina BSc, Sándor Szántó MD, PhD, DSc

Article Type

Original Research

Published

This study assessed the impact of adalimumab on clinical outcomes, healthcare resource utilization, and sick leave in patients with ankylosing spondylitis in five Central and Eastern Europe countries.

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The metabolic model of heart failure: the role of sodium glucose co-transporter-2 (SGLT-2) inhibition

Muhammad Saad MD, Umut Gomceli MD, Pranav Ravi MD, Andrisael G Lacoste MD, Neil Shah MD, Timothy J Vittorio MD

Article Type

Review

Published

In the recent era, SGLT-2 inhibitors have shown success in decreasing cardiovascular mortality in the type 2 diabetes mellitus population. This article will help the reviewer to comprehend the pathophysiology of heart failure and the potential role of SGLT-2 inhibitors in the management algorithm of heart failure and its associated risk factors in type 2 diabetes mellitus.

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Repurposing existing drugs for cardiovascular risk management: a focus on methotrexate

Arduino A Mangoni MD, PhD, FRCP, FRACP, Sara Tommasi PhD, Angelo Zinellu PhD, Salvatore Sotgia MSc, Ciriaco Carru PhD, Matteo Piga MD, Gian Luca Erre MD

Article Type

Review

Published

This review discusses the current challenges in the management of cardiovascular disease; the available evidence on the effects of methotrexate on inflammation, blood pressure, and surrogate markers of arterial function; suggestions for future research directions; and practical considerations with the use of methotrexate in this context.

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