Articles

Sensory properties analysis of a calcipotriol and betamethasone dipropionate cream vehicle formulated with an innovative PAD Technology for the treatment of plaque psoriasis on the skin and scalp

Nuria García, Pere Guiró, Jordi Galván, Nigel Crutchley, Morten Praestegaard, Lars Iversen, Tiago Torres

Article Type

Original Research

Published

This study characterizes the sensorial attributes of the calcipotriol
(CAL) and betamethasone dipropionate (BDP) polyaphron dispersion cream vehicle and compares them with the sensorial attributes of conventional formulations for psoriasis such as an ointment and an oleogel product.

Read more

High-rate breakthrough cancer pain and tumour characteristics – literature review and case series

Arturo Cuomo, Anastasios Boutis, Francesca Colonese, Davide Nocerino

Article Type

Review

Published

The aim of this narrative review is to explore the relationship between high-rate breakthrough cancer pain, which strongly impacts health-related quality of life and tumour characteristics, in the face of novel approaches that should provide guidance for future clinical practice.

Read more

HR+/HER2– de novo metastatic breast cancer:
a true peculiar entity?

Rosalba Torrisi, Flavia Jacobs, Chiara Miggiano, Rita De Sanctis, Armando Santoro

Article Type

Review

Published

This is a critical narrative review focusing on HR+/human epidermal growth factor receptor 2-negative (HER2–) de novo metastatic breast cancer in terms of genomic, biological, pathological, and clinical features and outcomes after systemic and locoregional treatments, outlining differences with recurrent metastatic breast cancer.

Read more

Upadacitinib for the treatment of psoriatic arthritis

Diogo Fonseca, Miguel Nogueira, Tiago Torres

Article Type

Review

Published

This article offers a review of the more recently published results on the Janus kinase inhibitor inhibitor upadacitinib and its use in the treatment of psoriatic arthritis.

Read more

Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Katayoun Derakhchan, Zhen Lou, Hong Wang, Robert Baughman

Article Type

Original Research

Published

Prucalopride is a selective serotonin type 4 (5-HT4) receptor agonist indicated for treatment of chronic idiopathic constipation in adults. 5-HT4 receptors are present in the central nervous system; therefore, this article discusses non-clinical and clinical assessments evaluating the tissue distribution and abuse potential of prucalopride.

Read more

Register for alerts

I would like to be contacted by Drugs in Context when new articles are posted.