Articles

Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

Katayoun Derakhchan, Zhen Lou, Hong Wang, Robert Baughman

Article Type

Original Research

Published

Prucalopride is a selective serotonin type 4 (5-HT4) receptor agonist indicated for treatment of chronic idiopathic constipation in adults. 5-HT4 receptors are present in the central nervous system; therefore, this article discusses non-clinical and clinical assessments evaluating the tissue distribution and abuse potential of prucalopride.

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How to design and implement an outpatient antimicrobial stewardship programme

Emily N Drwiega, Nicole Griffith, Fischer Herald, Melissa E Badowski

Article Type

Review

Published

This manuscript offers detailed guidance on how to design and implement an outpatient antimicrobial stewardship programme and reviews the literature on current strategies. Challenges related to initiating and maintaining outpatient stewardship efforts are also discussed

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Leveraging diagnostic stewardship within antimicrobial stewardship programmes

Kimberly C Claeys, Melissa D Johnson

Article Type

Review

Published

This review will discuss the need for diagnostic and antimicrobial stewardship, the interplay of diagnostic and antimicrobial stewardship, evidence of benefit to antimicrobial stewardship programmes, and considerations for successfully engaging in diagnostic stewardship interventions.

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A real-world retrospective study of omeprazole–domperidone combination in managing acid peptic disease with PRoton-pump Inhibitors in patients with type 2 DiabEtes mellitus (PRIDE-2)

Bharat Saboo, Nimmi Mulwani, Anup Uttam Petare, Krishna Chaitanya Veligandla, Colette Stephen Pinto, Amey Mane, Rahul Rathod, Bhavesh Kotak

Article Type

Original Research

Published

This article evaluates the effectiveness and safety of the omeprazole–domperidone combination amongst patients with type 2 diabetes mellitus for the management of acid peptic disease.

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