Articles - Drugs in Context

Adjuvant abemaciclib in early-stage breast cancer: hypothesis-generating safety observations from a real-world cohort study

Federico Sottotetti, Simone Figini, Giulia Gambini, Gianpiero Rizzo, Giulia Chessa, Erica Quaquarini, Raffaella Palumbo, Lorenzo Perrone, Barbara Tagliaferri, Alessandra Ferrari, Catherine Klersy, Paolo Pedrazzoli, Laura Deborah Locati, Angioletta Lasagna

Article Type

Original Research

Published

11 Dec 2025

This study aims to enhance comprehension of the clinical efficacy and safety of adjuvant abemaciclib in older women in a real-world setting compared with younger women.

Effectiveness of the antihistamine and anti-PAF effects of rupatadine in allergic diseases: off-label use in a case series study

Rita Aguiar, Rocío Concepción Albores-Arguijo, Ewa Cichocka-Jarosz, Joanna Jerzynska, Douglas P Mack

Article Type

Case Series

Published

09 Dec 2025

This case series shows the real-world effectiveness and safety of off-label rupatadine use in paediatric patients with clinically relevant complex allergy-related and dermatology-related conditions

Holistic care in mild upper respiratory tract infections (MURTIs): an approach to individualized care management

Andrew Smith, Guillermo Estrada Riolobos, Marco Biagi, Andreas Michalsen, Laura Sadofsky, Ann Herzeel, Patrick Poucheret

Article Type

Review

Published

04 Dec 2025

This article presents a patient-centred classification system for mild upper respiratory tract infections and proposes a 360° holistic care model that tailors effective, safe and suitable treatment to each individual’s symptoms and circumstances.

Deferiprone therapy improves the oxidative status of LDL in patients with β-thalassaemia/HbE

Ngan Thi Tran, Pakawit Lerksaipheng, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Ken-ichi Yamada, Noppawan Phumala Morales, Rataya Luechapudiporn

Article Type

Original Research

Published

02 Dec 2025

This study assesses the protective effect of deferiprone on the oxidative status of low-density lipoproteins in patients with β-thalassaemia/haemoglobin E.

Biologics and small molecules for psoriasis: current and future progress

Luca Potestio, Nello Tommasino, Michela D’Agostino, Valeria Esposito, Giuseppe Lauletta, Antonio Portarapillo, Matteo Megna

Article Type

Review

Published

20 Nov 2025

This narrative review explores new systemic therapies for psoriasis, including both approved and emerging biologics and small molecules, highlighting future directions in treatment.