Articles - Drugs in Context

Is carvedilol superior to propranolol in patients with cirrhosis with portal hypertension: a systematic and meta-analysis

Siddheesh Rajpurohit, Balaji Musunuri, Pooja Basthi Mohan, Ganesh Bhat, Shiran Shetty

Article Type

Review

Published

24 Feb 2025

This study evaluates the efficacy and safety of carvedilol compared with propranolol in managing portal hypertension.

Obinutuzumab in membranous nephropathy: a potential game-changer in treatment

Concetto Sessa, Dario Galeano, Luca Zanoli, Marco Delsante, Giovanni Maria Rossi, Walter Morale

Article Type

Review

Published

21 Feb 2025

This articles reviews the pathophysiology of membranous nephropathy (MN), the mechanism of action of obinutuzumab, clinical data supporting its use and discusses its potential as a game changer in MN treatment.

Real-life effectiveness of FLOT in resectable gastric cancer: existing challenges

Francesco Serra, Federica Valerio, Paolo Pedrazzoli, Jacopo Viganò, Riccardo Caccialanza, Daniela Cicognini, Anna Pagani, Salvatore Corallo

Article Type

Original Research

Published

18 Feb 2025

This article aims to demonstrate the real-life effectiveness of the fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT) regimen by comparing it with traditional chemotherapy regimens and aims to discover its strengths and weaknesses.

Real-world assessment of effectiveness and safety of filgotinib in 286 patients with ulcerative colitis in 9 UK centres

David Young, Sohail Rahmany, Deborah Taylor, Emma Davis, Michael Colwill, Sonia Kalyanji Mehta, Roisin Campbell, Karl Hazel, Karishma Sethi-Arora, Susan Ritchie, Ashley I Heinson, Helen Moyses, Keith Bodger, Emma Johnston, Lucy Hicks, Anjan Dhar, Jimmy Limdi, Rachel Cooney, John Paul Seenan, Kamal Patel, Alissa Walsh, Fraser Cummings

Article Type

Original Research

Published

29 Jan 2025

This article reports the real-world
experience of 286 patients with ulcerative colitis treated with filgotinib as part of their routine clinical care in 9 UK centres.

Role of aspirin in the primary prevention of cardiovascular disease in patients with hyperlipoproteinaemia(a)

Eleni Giannopoulou, Loukianos S Rallidis, Donatos Tsamoulis, Maria Gianniou, Constantine E Kosmas

Article Type

Review

Published

31 Dec 2024

This comprehensive review aims to provide readers with the current data on the use of aspirin as a primary prevention tool for atherosclerotic cardiovascular disease in patients with elevated lipoprotein(a) levels.