A prospective, observational, multicentre study to evaluate the efficacy of brivaracetam as adjuvant therapy for epilepsy: The Bravo study

Fowzia Siddiqui, Bashir A Soomro, Ehsan U Rehman, Ahsan Numan, Safia Bano, Jawwad Us Salam, Hazim Brohi, Muhammad Zaheer, Faizan Hyder Memon, Muhammad Wahab Qureshi, Junaid Ahmed Sheikh, Abdul Latif Sunejo, Amjad Iqbal, Saira Abbass, Saba Zaidi, Sidrah Nawaz, Kaukab Fatima, Samar Altaf, Neeta Maheshwary, Muhammad Athar Khan, Arjumand Ahmed, Muhammad Iqbal Asif

Article Type

Original Research

Published

The objective of this study was to assess the effectiveness of Brivera when used as an adjunctive therapy for individuals diagnosed with epilepsy.

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Understanding treatment goals and their application in clinical trial design for patients with Alzheimer disease and caregivers

David Gómez-Ulloa, M Chris Runken, Wilton I Rodriguez, Basilio Hernández, Montserrat Chivite, E Anne Davis, Paul Nisbet

Article Type

Original Research

Published

The goal of the present study was to survey patients with AD and caregivers to establish what they considered to be the most important treatment goals, thereby providing data for the systematic incorporation of these goals into Alzheimer disease clinical trials.

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Sleep-related breathing disorder (central sleep apnoea) improved coincidentally by medical therapy with fumarates (dimethyl fumarate)

Abdulmajeed M Albadi, Mana M Alshahrani, Riyad O Allehebi

Article Type

Case Report

Published

In this article, the authors describe a case study of a 31-year-old woman known to have multiple sclerosis and concomitant severe central sleep apnoea (CSA). She received the medication dimethyl fumarate for the treatment of multiple sclerosis, and her CSA significantly improved to mild CSA after the treatment.

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Lurasidone for the treatment of schizophrenia in adult and paediatric populations

Teresa Guilera, Juan Pablo Chart Pascual, Maria del Carmen Blasco, Pilar Calvo Estopiñán, Rubén Asensio Piernas González, Isabel Ramírez Martínez, Cristóbal Rodríguez Moyano, Rita Prieto Pérez, Irene Gabarda-Inat, Juan L Prados-Ojeda, Marina Diaz-Marsà, Manuel Martín-Carrasco

Article Type

Review

Published

In this review, the lurasidone development programme for adult and paediatric patients is described. In addition, the pharmacokinetic and pharmacodynamic characteristics of lurasidone are revisited, pivotal clinical studies conducted on both adults and children are summarized, and several clinical cases are also presented.

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