Relationship between breakthrough cancer pain, background cancer pain and analgesic treatment – case series and review of the literature

Chrysanthi Batistaki, Michal Graczyk, Marcin Janecki, Agata Anna Lewandowska, Rita Moutinho, Kiriaki Vagdatli

Article Type

Review

Published

The aim of this paper is to provide healthcare professionals involved in cancer pain management with a review of the relevant literature on the relationship between background cancer pain and breakthrough cancer
pain.

Read more

Deferiprone, an iron chelator, alleviates platelet hyperactivity in patients with β-thalassaemia/HbE

Ngan Thi Tran, Pranee Sutcharitchan, Jindaporn Janprasit, Ponlapat Rojnuckarin, Noppawan Phumala Morales, Rataya Luechapudiporn

Article Type

Original Research

Published

This study was designed to evaluate the antiplatelet effect of deferiprone in patients with transfusion-dependent β-thalassaemia/Hb E at the dose of iron-chelation therapy. The results may provide a mechanistic insight in antiplatelet effects and support the benefit of deferiprone in the prevention of thrombotic events in β-thalassaemia.

Read more

How to manage KRAS G12C-mutated advanced non-small-cell lung cancer

Biagio Ricciuti, Alessia Mira, Elisa Andrini, Pietro Scaparone, Sandra Vietti Michelina, Federica Pecci, Luca Cantini, Andrea De Giglio, Giuseppe Lamberti, Chiara Ambrogio, Giulio Metro

Article Type

Review

Published

The authors review the current treatment landscape for patients with advanced non-small-cell lung cancers harbouring a KRAS G12C mutation, including PD-(L) 1-based therapies and direct KRAS inhibitors as well as sequential treatment options.

Read more

Nutritional support management in resectable gastric cancer

Francesco Serra, Paolo Pedrazzoli, Silvia Brugnatelli, Anna Pagani, Salvatore Corallo, Giovanni Rosti, Riccardo Caccialanza, Jacopo Viganò, Ornella Carminati

Article Type

Review

Published

This narrative review presents the most recent data on nutritional support in the resectable stages of gastric cancer, with a particular focus on perioperative strategies, and discusses malnutrition in gastric cancer, nutritional support before and after surgery, and the relationship between nutritional support and chemotherapy.

Read more

Small bowel villous atrophy due to immune-checkpoint inhibitors: report of two cases and literature review

Annalisa Schiepatti, Andrea Premoli, Stiliano Maimaris, Mimma Rizzo, Maria Marples, Laura Villani, Nigel Scott, Federico Sottotetti, David S Sanders, Federico Biagi, Clare Donnellan

Article Type

Case Report

Published

This article describes two cases of enteropathy with villous atrophy due to immune-checkpoint inhibitors, which may broaden the differential diagnosis of non-coeliac enteropathies and may represent a pathogenetic model for the understanding of the molecular mechanisms involved in these enteropathies. A narrative review is also provided, summarizing the current evidence on the adverse events of immune-checkpoint inhibitors involving the small bowel.

Read more

Register for alerts

I would like to be contacted by Drugs in Context when new articles are posted.