Brodalumab in psoriasis: evidence to date and clinical potential

Amy C Foulkes BMedSci (Hons), BMBS, MRCP (Derm), PhD, Richard B Warren BSc (Hons), MBChB (Hons), MRCP, PhD

Abstract

Brodalumab is a recombinant, fully human monoclonal antibody (IgG2) which binds with high affinity to the interleukin (IL) 17 receptor A (IL17R). Brodalumab is now licensed and approved for the treatment of moderate-to-severe chronic plaque psoriasis in North America and Europe. As the third to market in the class of agents targeting IL-17, we review its place in the expanding armamentarium of cytokine-directed therapies for patients with severe psoriasis. Brodalumab is a highly efficacious therapy for psoriasis, whose mechanism of action is separate from other treatments targeting IL-17. Its use is associated with rapid control of the disease. We suggest that brodalumab is likely to be considered in those patients requiring rapid control of disease, where there is no known history of depression or suicidal ideation.

Article Details

Article Type

Review

DOI

10.7573/dic.212570

Publication Dates

Accepted: ; Published: .

Citation

Foulkes AC, Warren RB. Brodalumab in psoriasis: evidence to date and clinical potential. Drugs in Context 2019; 8: 212570. DOI: 10.7573/dic.212570

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