Bispecific antibodies for non-Hodgkin’s lymphomas and multiple myeloma

Omar Castaneda-Puglianini, Julio C Chavez

Abstract

Immunotherapy has revolutionized the treatment of cancers. There are several approaches, including naked monoclonal antibodies, antibody–drug conjugates, immune-checkpoint inhibitors and chimeric antigen receptor T cell therapies with important success. Bispecific antibodies represent a novel immunotherapeutic approach for the treatment of several malignancies, in particular non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM). Early-phase studies have shown encouraging clinical activity in poor-risk B cell NHL and MM. Several constructs are currently available and in clinical development for the treatment of these malignancies. Here, we present a narrative review of the most current data on bispecific antibodies in B cell NHL and MM.

Article Details

Article Type

Review

DOI

10.7573/dic.2021-2-4

Publication Dates

Accepted: ; Published: .

Citation

Castaneda-Puglianini O, Chavez JC. Bispecific antibodies for non-Hodgkin’s lymphomas and multiple myeloma. Drugs Context. 2021;10:2021-2-4. https://doi.org/10.7573/dic.2021-2-4

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